Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cadherin + H2O | Homo sapiens | - |
? | - |
? | |
cadherin + H2O | Mus musculus | - |
? | - |
? | |
low-density lipoprotein + H2O | Homo sapiens | - |
? | - |
? | |
low-density lipoprotein + H2O | Mus musculus | - |
? | - |
? | |
additional information | Homo sapiens | the enzyme does not hydrolyze high-density lipoprotein | ? | - |
? | |
additional information | Mus musculus | the enzyme does not hydrolyze high-density lipoprotein | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08311 | - |
- |
Mus musculus | P28293 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood plasma | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
smooth muscle cell | - |
Homo sapiens | - |
smooth muscle cell | - |
Mus musculus | - |
T-lymphocyte | - |
Homo sapiens | - |
T-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cadherin + H2O | - |
Homo sapiens | ? | - |
? | |
cadherin + H2O | - |
Mus musculus | ? | - |
? | |
low-density lipoprotein + H2O | - |
Homo sapiens | ? | - |
? | |
low-density lipoprotein + H2O | - |
Mus musculus | ? | - |
? | |
additional information | the enzyme does not hydrolyze high-density lipoprotein | Homo sapiens | ? | - |
? | |
additional information | the enzyme does not hydrolyze high-density lipoprotein | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatG | - |
Homo sapiens |
CatG | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | patients with atherosclerosis have significantly reduced plasma enzyme levels | down |
Mus musculus | patients with atherosclerosis have significantly reduced plasma enzyme levels | down |
General Information | Comment | Organism |
---|---|---|
malfunction | the absence of cathepsin G reduces arterial wall elastin degradation and attenuates early atherosclerosis when mice consume a Western diet for 3 months | Mus musculus |
physiological function | cathepsin G activity lowers plasma low-density lipoprotein and reduces atherosclerosis. The enzyme promotes early atherogenesis through its elastinolytic activity, but suppresses late progression of atherosclerosis by degrading low-density lipoprotein without affecting high-density lipoprotein or triglycerides | Homo sapiens |
physiological function | cathepsin G activity lowers plasma low-density lipoprotein and reduces atherosclerosis. The enzyme promotes early atherogenesis through its elastinolytic activity, but suppresses late progression of atherosclerosis by degrading low-density lipoprotein without affecting high-density lipoprotein or triglycerides | Mus musculus |